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Off the Press:

Aug 9th, 2019
Grats to Dr. Kelsey Johnson on a successful thesis defense! Best of luck to her as a post-doc with Frank Albert and Ran Blekhman!

July 25th, 2019
Grats to Kat who is a semi-finalist for the 2019 Charles J. Epstein Predoc Trainee Awards for Excellence in Human Genetics Research!

July 24th, 2019
Grats to Diana who is a finalist for the 2019 Charles J. Epstein Postdoc Trainee Awards for Excellence in Human Genetics Research!

July 5th, 2019
Grats to Diana on winning a K99/R00 award!!!

April 23rd, 2019
Grats to Katie on winning a Saul Winegrad Award for Outstanding Disseration in GCB!!

April 19th, 2019
Grats to Dr. Katie Siewert on a successful thesis defense! Best of luck to her as a post-doc with Alkes Price!

Feb 7th, 2019
Rocky and Kelsey's paper on private mutations across sequence context is online at MBE!

Jan 31st, 2019
Diana's paper on COL1A1 variation on bone accretion in girls is out at Bone!

Snapshot while in the Field.

Positions Available!

My lab has openings for computational post-doctoral positions. Please click here for more information.

The Things I Do

I am a statistical and population geneticist interested in understanding the relationship between DNA sequence variation and complex human diseases or traits. To build this understanding, my lab constructs statistical and computational methods grounded in principles of population biology, applying them to genetic data collected across whole genomes. A central objective of my lab is to uncover how genetic variation contributes to the diverse set of traits evolved over recent human history and to the range of diseases we find today. My research has answered population genetic questions about recent demographic and selective events in human populations, and more recently I have focused on mapping risk alleles for common diseases, particularly type-2 diabetes and heart attack. I have also contributed to novel statistical approaches for population genetic inference, disease mapping studies, causal inference studies via Mendelian Randomization, as well as leading the development of next generation sequencing and genotypic assay technologies designed to improve characterization of genetic variation in the human genome.

My Roots

Advised by Drs. Jonathan Pritchard and Nancy Cox, in 2006 I received my Ph.D. in Human Genetics at the University of Chicago. As a post-doctoral research fellow from 2006-2009, I worked with Drs. David Altshuler and Mark Daly at the Center of Human Genetics Research at Massachusetts General Hospital. From 2009 until September of 2011, I remained at the Broad Institute of Harvard and MIT as a Research Scientist. In September of 2011, I joined the faculty ranks of the Departments of Systems Pharmacology and Translational Therapeutics and Genetics at the University of Pennsylvania Perelman School of Medicine as an Assistant Professor. In 2017, I was promoted to Associate Professor (with tenure). I am also a member of the Institute for Translational Medicine and Therapeutics and the Institute for Biomedical Informatics. I serve as the chairman for the Genomics and Computational Biology graduate program, and as a co-director of the Bioinformatics Concentration for the Master of Science in Translational Research here at Penn.

A current copy of my CV can be found here: [PDF-OCT19]