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Off the Press:

Feb 7th, 2019
Rocky and Kelsey's paper on private mutations across sequence context is online at MBE!

Jan 31st, 2019
Diana's paper on COL1A1 variation on bone accretion in girls is out at Bone!

Dec 17th, 2018
Katie's paper on a bivariate GWAS for Lipids and CHD is out at Circulation: Genomics and Precision Medicine!

Nov 13th, 2018
Grats to Diana for being selected for CHOP 2019 Distinguished Research Trainee Award!

Nov 8th, 2018
Grats to Kat for receiving an AHA pre-doctoral Fellowship!

Aug 1st, 2018
Grats to Kat: her abstract was selected for a talk at ASHG!

Jul 17th, 2018
Paul and Sumeet's paper on the MIP target capture in HDL-C extremes is out at Circulation: Genomics and Precision Medicine!

June 21st, 2018
Chris is a Foerderer Award recipient for 2018! Nice job!

Snapshot while in the Field.

Positions Available!

My lab has openings for computational post-doctoral positions. Please click here for more information.

The Things I Do

I am a statistical and population geneticist interested in understanding the relationship between DNA sequence variation and complex human diseases or traits. To build this understanding, my lab constructs statistical and computational methods grounded in principles of population biology, applying them to genetic data collected across whole genomes. A central objective of my lab is to uncover how genetic variation contributes to the diverse set of traits evolved over recent human history and to the range of diseases we find today. My research has answered population genetic questions about recent demographic and selective events in human populations, and more recently I have focused on mapping risk alleles for common diseases, particularly type-2 diabetes and heart attack. I have also contributed to novel statistical approaches for population genetic inference, disease mapping studies, causal inference studies via Mendelian Randomization, as well as leading the development of next generation sequencing and genotypic assay technologies designed to improve characterization of genetic variation in the human genome.

My Roots

Advised by Drs. Jonathan Pritchard and Nancy Cox, in 2006 I received my Ph.D. in Human Genetics at the University of Chicago. As a post-doctoral research fellow from 2006-2009, I worked with Drs. David Altshuler and Mark Daly at the Center of Human Genetics Research at Massachusetts General Hospital. From 2009 until September of 2011, I remained at the Broad Institute of Harvard and MIT as a Research Scientist. In September of 2011, I joined the faculty ranks of the Departments of Systems Pharmacology and Translational Therapeutics and Genetics at the University of Pennsylvania Perelman School of Medicine as an Assistant Professor. I am also a member of the Institute for Translational Medicine and Therapeutics and the Institute for Biomedical Informatics.

A current copy of my CV can be found here: [PDF-FEB19]