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Off the Press:

February 28th, 2017
Diana's LADA GWAS abstract selected for a talk at the ADA!

January 19th, 2017
Katie's talk at the NY area Popgen meeting goes brilliantly! Great job Katie!

January 9th, 2017
Ben is selected for a PECASE!

October 28th, 2016
Rocky's MR paper for SBP and T2D paper is out at Diabetes!

October 14th, 2016
Congrats to Diana for earning a post-doc fellowship from the ADA!

September 11th, 2016
Diana's paper on interpretation of HME variants using ExAC is out at Bone!

Snapshot while in the Field.

Positions Available!

My lab has openings for computational post-doctoral positions. Please click here for more information.

The Things I Do

I am a statistical and population geneticist interested in understanding the relationship between DNA sequence variation and complex human diseases or traits. To build this understanding, my lab constructs statistical and computational methods grounded in principles of population biology, applying them to genetic data collected across whole genomes. A central objective of my lab is to uncover how genetic variation contributes to the diverse set of traits evolved over recent human history and to the range of diseases we find today. My research has answered population genetic questions about recent demographic and selective events in human populations, and more recently I have focused on mapping risk alleles for common diseases, particularly type-2 diabetes and heart attack. I have also contributed to novel statistical approaches for population genetic inference, disease mapping studies, causal inference studies via Mendelian Randomization, as well as leading the development of next generation sequencing and genotypic assay technologies designed to improve characterization of genetic variation in the human genome.

My Roots

Advised by Drs. Jonathan Pritchard and Nancy Cox, in 2006 I received my Ph.D. in Human Genetics at the University of Chicago. As a post-doctoral research fellow from 2006-2009, I worked with Drs. David Altshuler and Mark Daly at the Center of Human Genetics Research at Massachusetts General Hospital. From 2009 until September of 2011, I remained at the Broad Institute of Harvard and MIT as a Research Scientist. In September of 2011, I joined the faculty ranks of the Departments of Systems Pharmacology and Translational Therapeutics and Genetics at the University of Pennsylvania Perelman School of Medicine as an Assistant Professor. I am also a member of the Institute for Translational Medicine and Therapeutics and the Penn Center for Bioinformatics.

A current copy of my CV can be found here: [PDF-MAR17]