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Off the Press:

April 14th, 2016
Welcome to new lab members Katerina and Onur!

February 22nd, 2016
Congrats to Varun: His paper out in Nature Genetics!

September 23rd, 2015
Congrats to Kim selected for Penn's Diabetes post-doc T32!

September 18th, 2015
Varun's poster was a winner for best in show at the Penn Genetics Retreat!

September 15th, 2015
Welcome to new lab member Diana!

Snapshot while in the Field.

Positions Available!

My lab has openings for computational post-doctoral and wet-lab technician positions. Please click here for more information.

The Things I Do

I am a statistical and population geneticist interested in understanding the relationship between DNA sequence variation and complex human diseases or traits. To build this understanding, my lab constructs statistical and computational methods grounded in principles of population biology, applying them to genetic data collected across whole genomes. A central objective of my lab is to uncover how genetic variation contributes to the diverse set of traits evolved over recent human history and to the range of diseases we find today. My research has answered population genetic questions about recent demographic and selective events in human populations, and more recently I have focused on mapping risk alleles for common diseases, particularly type-2 diabetes and heart attack. I have also contributed to novel statistical approaches for population genetic inference, disease mapping studies, causal inference studies via Mendelian Randomization, as well as leading the development of next generation sequencing and genotypic assay technologies designed to improve characterization of genetic variation in the human genome.

My Roots

Advised by Drs. Jonathan Pritchard and Nancy Cox, in 2006 I received my Ph.D. in Human Genetics at the University of Chicago. As a post-doctoral research fellow from 2006-2009, I worked with Drs. David Altshuler and Mark Daly at the Center of Human Genetics Research at Massachusetts General Hospital. From 2009 until September of 2011, I remained at the Broad Institute of Harvard and MIT as a Research Scientist. In September of 2011, I joined the faculty ranks of the Departments of Systems Pharmacology and Translational Therapeutics and Genetics at the University of Pennsylvania Perelman School of Medicine as an Assistant Professor. I am also a member of the Institute for Translational Medicine and Therapeutics and the Penn Center for Bioinformatics.

A current copy of my CV can be found here: [PDF-APR16]