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Off the Press:

Feb 22nd, 2018
Kelsey's paper on Shared Sweeps is out at Nature E&E! Also, her blog post on the subject!

Sept. 15th, 2017
Ben selected for the Michael S. Brown New Investigator Research Award!

August 16th, 2017
Hats tipped to Katie: her abstract was selected for a talk at MEM!

July 21st, 2017
Katie's paper on Balancing Selection is Accepted at MBE!

June 8th, 2017
Congrats to Chris on receiving the 2016-17 Senior Resident Research Award at CHOP!

June 1st, 2017
Congrats to Kat for receiving a 2017 American Polish Cultural Society Scholarship!

May 26th, 2017
Paul's Spider Genomics paper makes the cover of the June issue of NG!!

Snapshot while in the Field.

Positions Available!

My lab has openings for computational post-doctoral positions. Please click here for more information.

The Things I Do

I am a statistical and population geneticist interested in understanding the relationship between DNA sequence variation and complex human diseases or traits. To build this understanding, my lab constructs statistical and computational methods grounded in principles of population biology, applying them to genetic data collected across whole genomes. A central objective of my lab is to uncover how genetic variation contributes to the diverse set of traits evolved over recent human history and to the range of diseases we find today. My research has answered population genetic questions about recent demographic and selective events in human populations, and more recently I have focused on mapping risk alleles for common diseases, particularly type-2 diabetes and heart attack. I have also contributed to novel statistical approaches for population genetic inference, disease mapping studies, causal inference studies via Mendelian Randomization, as well as leading the development of next generation sequencing and genotypic assay technologies designed to improve characterization of genetic variation in the human genome.

My Roots

Advised by Drs. Jonathan Pritchard and Nancy Cox, in 2006 I received my Ph.D. in Human Genetics at the University of Chicago. As a post-doctoral research fellow from 2006-2009, I worked with Drs. David Altshuler and Mark Daly at the Center of Human Genetics Research at Massachusetts General Hospital. From 2009 until September of 2011, I remained at the Broad Institute of Harvard and MIT as a Research Scientist. In September of 2011, I joined the faculty ranks of the Departments of Systems Pharmacology and Translational Therapeutics and Genetics at the University of Pennsylvania Perelman School of Medicine as an Assistant Professor. I am also a member of the Institute for Translational Medicine and Therapeutics and the Institute for Biomedical Informatics.

A current copy of my CV can be found here: [PDF-OCT17]